Allopurinol Dosage
Allopurinol Dosage for Gout (Adult): Initial Allopurinol Dosage is 100 mg orally once a day.
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Allopurinol Dosage for Hyperuricemia Secondary to Chemotherapy (Adults): Initial: Parenteral: 200 to 400 mg/m2/day to a maximum of 600 mg/day. Oral: 600 to 800 mg/day for 1 to 3 days with consumption of at least 2 L of fluid/day.
Maintenance: 200 to 300 mg/day orally until patient no longer at high risk for developing hyperuricemia.
Allopurinol for Calcium Oxalate Calculi with Hyperuricosuria (Adult): Initial: 200 to 300 mg orally once a day.
Allopurinol for Congestive Heart Failure (Adults): 300 mg orally daily for 1 month
Allopurinol for Cardiothoracic Surgery (Adults): 600 mg orally one day prior to surgery and another 600 mg orally the day of surgery.
Allopurinol for Leishmaniasis (Adults): 20 mg/kg/day plus low-dose meglumine antimoniate (30 mg/kg/day) for 20 days.
Allopurinol Dosage for Manian (Adults): 300 mg orally daily.
Allopurinol Dosage for High Risk Percutaneous Transluminal Angioplasty (Adults): 400 mg orally administered immediately after admission to the emergency department and after primary PTCA was completed.
Allopurinol Dosage for Reactive Perforating Collangenosis (Adults): 100 mg orally daily.
Allopurinol Dosage for Hyperuricemia Secondary to Chemotherapy (Adults): Parenteral : Less than or equal to 10 years: 200 mg/m2/day in 1 to 3 equally divided doses not to exceed 600 mg/24 hours. Oral: Less than 6 years: 150 mg/day orally in 3 divided doses. 6 to 10 years: 300 mg/day orally in 2 to 3 divided doses. Greater than 10 years: 600 to 800 mg/day in 2 to 3 equally divided doses
Allopurinol Dosage (Children): Children greater than 5 years old: 20 mg/kg/day plus low-dose meglumine antimoniate (30 mg/kg/day) for 20 days. Allopurinol Dosage Adjustments The dose should be titrated at weekly intervals to achieve the desired response in gout. Normal serum urate levels of 6 mg/dl or less are usually achieved in 1 to 3 weeks. Doses greater than 300 mg/day should be given in divided doses. Allopurinol Dosage or injection in combination therapy with mercaptopurine or azathioprine will require dose reductions of one-third to one-fourth the usual dose of mercaptopurine or azathioprine. The dose of the uricosuric agent should be gradually reduced over a period of several weeks in transferring a patient from a uricosuric agent to allopurinol.
Warning:
If the first sign of skin rash or any other signs or symptoms noticed, Allopurinol Dosage should be stopped. In some cases a skin rash may be followed by more severe adverse reactions such as exfoliative, urticarial, and purpuric lesions, as well as Stevens-Johnson syndrome, and/or generalized vasculitis, irreversible hepatotoxicity, and, rarely, death. Renal dysfunction increases the risk of allopurinol hypersensitivity.
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